NEW YORK (Dow Jones)--Overnight, Human Genome Sciences Inc. (HGSI) went from a biotech company with questionable prospects and a challenging balance sheet, to an attractive takeover target with a potential blockbuster drug for lupus, a notoriously hard-to-treat autoimmune disease.

The staggering move Monday in the Rockville, Md., company's stock - which more than tripled to $10.73, adding a billion dollars to the company's market value - comes from the drug's multibillion-dollar market prospects, but also from the removal of concerns hanging over the company.

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